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Metrics details. Toll-like receptor 9 agonists are potent activators of the immune system. Their clinical potential in immunotherapy against metastatic cancers is being evaluated across a number of clinical trials. Chemical modifications of DNA backbones are usually employed to prevent degradation by nucleases. These, however, can promote undesirable off-target effects and therapeutic restrictions. Selected molecules were evaluated in mice in a maximum feasible dose study and for analysis of immune activation. The absence of off-target effects may enable a wide therapeutic window. This advantageous anti-tumoral immune profile also promotes increased T cell infiltration into CT26 colon carcinoma tumors, which translates into reduced tumor growth. Toll-like receptors TLR belong to the group of pattern recognition receptors PRR that identify pathogen-associated molecular patterns PAMP , which are ubiquitously presented by pathogens but are essentially absent in vertebrates. TLR enable immune cells to fight pathogens by first activating the innate immune response, followed by the induction of antigen-specific effector- as well as memory T cells of adaptive immunity.

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Ever had that tune you just couldn’t get out of your head, but you couldn’t remember the darn title or who the heck performed the track? Well there’s an app for that. Actually, there are several.

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Skip navigation! Story from Movies. Valley Girl is a jukebox teen musical dreamt up by a cool mom, played by Alicia Silverstone. It’s all very The Princess Bride with Silverstone’s Julie telling her teen daughter the story of her high school crush. Julie’s story isn’t about a princess, though, just a girl falling in love to some of the biggest hits of the ’80s.

It’s safe to say, the Valley Girl soundtrack is like totally rad. Not unlike the movie it’s based on: the teen comedy Valley Girl starring young Nicolas Cage. The new film puts a Glee- esque spin on the story of a popular girl falling for a guy from the wrong side of the tracks. In order for this update to work, Valley Girl ‘s writer Amy Talkington told Refinery29 that the movie’s songs had “to be in the DNA of the script and the story.

We worked really really hard to find songs that could tell our story and define our characters and create the tone that we needed. Goldenberg also wanted to pay tribute to the OG Valley Girl ‘s soundtrack.


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Gattaca is a American dystopian science fiction film written and directed by Andrew Niccol. The film draws on concerns over reproductive technologies that facilitate eugenics, and the possible consequences of such technological developments for society. It also explores the idea of destiny and the ways in which it can and does govern lives.

Characters in Gattaca continually battle both with society and with themselves to find their place in the world and who they are destined to be according to their genes. The film’s title is based on the letters G, A, T, and C, which stand for guanine , adenine , thymine , and cytosine , the four nucleobases of DNA. In the future, eugenics is common. A genetic registry database uses biometrics to classify those so created as “valids” while those conceived by traditional means and more susceptible to genetic disorders are known as “in-valids”.

Genetic discrimination is illegal, but in practice genotype profiling is used to identify valids to qualify for professional employment while in-valids are relegated to menial jobs. Vincent Freeman is conceived without the aid of genetic selection; his genetic profile indicates a high probability of several disorders and an estimated lifespan of His parents, regretting their decision, use genetic selection in conceiving their next child, Anton.

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It truly sounds like their best Japanese album to date for so many reasons. Although Big Hit Entertainment was staying mum on the rumored project, fans were excited because it’s been a while since BTS released a full-length Japanese project. In April , they dropped their Japanese album Face Yourself. American fans will have to wait a little longer to get a physical album in their hands, however, since the album won;t ship in the U.

MotS: 7 – The Journey will have a whopping 13 tracks. Nine will be Japanese versions of songs ARMYs already heard, but four of those tracks will be totally new. The band has filmed a music video for the song, but it’s unclear if it will drop on June 19 along with the song or be released later. If these details already have you pumped, wait until they hear the rest of the album details.

Each album version will include a different set of goodies. For example, the limited editions will come with a booklet, a luxurious sleeve case, and stickers, while the regular editions will bring a lyrics booklet and trading card. Fans can also expect a lyrics booklet and trading card for the Universal Music Store and the Japan Official Fanclub editions.

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What do Lizzo, Maggie Rogers, and Sigrid have in common? Aside from releasing breakout albums in , each artist has had her music featured on the third season of Freeform’s hit dramedy The Bold Type. Part juicy journalism drama, part Sex and the City -esque comedy, the series — which chronicles the lives of three besties working for a glossy women’s magazine in Manhattan — has resonated because it tackles vital issues that young women face today, like sexism, cancel culture, and Internet harassment.

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All music genres have certain things that make them tick. Alexander is a music analyst with Pandora. The Internet radio company uses analysts with backgrounds in musicology, performance or composition as part of its Music Genome Project to categorize music based on different attributes for stations, including a station dedicated to video game music. While once a more narrowly defined genre, Alexander said game music is now most comparable to film scores both in that it can mimic numerous styles to fit the tone of the game, but also that it tends to blend conventions of multiple music genres.

Whereas if you don’t listen to much classical music, you might get totally lost. Game music varies widely. Generally speaking, however, game music places melody as king with driving but approachable rhythms and a simple harmonic language. Those qualities often are influenced by American popular music. Alexander said that usually the popularity of the music has to do with the popularity of the game the music is from.

In some ways, game composers must think of their audience as active participants in the way their music is performed.

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