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What Happened: The study was a randomized, double-blind, placebo-controlled trial using Spartalizumab — an investigational monoclonal antibody, alongside Tafinlar and Mekinist. The evaluation was conducted in three parts and the declared results were from the final stages of testing, Novartis said. Why It Matters: The company noted it intended to continue Spartalizumab development, despite negative clinical trial results. Price Action: Novartis shares closed 0. The stock gained 0. Novartis AG announced on Saturday that its investigational spartalizumab immunotherapy drug combined with Tafinlar and Mekinist therapies failed to meet its primary endpoint in a late-stage trial for the treatment of a type of advanced skin cancer. The trial was conducted among untreated patients with unresectable or metastatic stage IV BRAF V mutation-positive cutaneous melanoma, compared to the treatment of Tafinlar and Mekinist alone. Spartalizumab is an investigational monoclonal antibody directed against the human programmed death-1 PD-1 receptor. In addition, the Swiss drugmaker said that it will continue to explore new uses for immunotherapy in cancer treatment, including the ongoing development of spartalizumab, across a range of tumor types.

Music piracy site closed after U.K., Dutch raids

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Considered one of the world’s largest illegal sources of prerelease music, members-only service was focus of a two-year investigation. The raids in Amsterdam and the northeast English city of Middlesbrough followed a two-year investigation into a members-only Web site, which allowed users to upload and download albums before their release. Prerelease leaks have become one of the most damaging forms of piracy for the music industry which is struggling with falling sales. Recorded music sales have fallen by more than a third in the last six years, the industry says.

An estimated , members paid “donations” via debit or credit cards for OiNK’s catalog of music and other media. Industry experts said the site had provided access to more than 60 albums before their release this year alone. This was a worldwide network that got hold of music they did not own the rights to and posted it online. Prerelease piracy is regarded as particularly damaging because it leads to unauthorized mixes or unfinished versions of artists’ recordings appearing months before they are meant to.

Often it is those in the industry, who get promotional or demonstration copies of albums before their release, who are involved in leaking them to file-sharing sites. British police said they arrested the year-old on suspicion of conspiracy to defraud and infringement of copyright law. Dutch police seized servers and other computer equipment. Artists are experimenting with new ways of distributing their music to fans, including providing it free over the Internet.

British band Radiohead released its latest album on the Web and invited fans to pay a donation to download it. A raid in Sweden last year shut down an Internet site that police said was a major source of music and film piracy.

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